GLP-1 + GIP medications are a class of treatments that activate two incretin hormone pathways: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These pathways are deeply involved in regulating hunger, digestion, insulin release, and metabolic balance.

By engaging both receptors, dual-action medications can offer broader metabolic support compared to single-pathway treatments.

These medications must be used alongside lifestyle changes—such as improved nutrition and physical activity—for best results.

Dual-action medications work by stimulating both GLP-1 and GIP receptors, creating a combined effect on metabolic regulation.

They help:

• Reduce cravings and appetite

• Slow digestion to increase fullness and satiety

• Improve insulin sensitivity

• Support more stable blood sugar levels

This multi-hormone approach is designed to support healthier metabolic patterns over time.

Some FDA-approved dual-action medications are approved for chronic weight management. Others are approved for type 2 diabetes but may demonstrate appetite or metabolic effects.

Compounded GLP-1 + GIP medications are not FDA-approved, but licensed providers may prescribe them when clinically appropriate based on patient needs.

Many individuals notice reduced appetite within the first several weeks, especially as the dose increases. Changes in eating patterns often develop early, followed by broader metabolic improvements.

More pronounced benefits—such as sustained reductions in cravings, steadier energy levels, or improved metabolic response—typically appear over several weeks to several months depending on dose, consistency, and individual physiology.

GLP-1 + GIP medications may be appropriate for adults with:

• Obesity

• Overweight and at least one weight-related health condition

• Difficulty regulating appetite or cravings

• Metabolic challenges such as insulin resistance

Eligibility is always determined through a full medical consultation with a Good Girl Rx provider.

No. Compounded GLP-1 + GIP medications are not FDA-approved.
However, they may be prescribed legally by licensed healthcare providers when FDA-approved products:

• Are unavailable

• Are on national shortage

• Are not clinically appropriate for the patient

Compounding pharmacies follow regulated standards to prepare patient-specific medications.

The most common side effects involve the digestive system. These may include:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Stomach discomfort

These effects often improve as your body adjusts. Your provider can offer strategies to help manage them.

No. Dual-action treatments should not be used alongside:

• GLP-1 agonists

• Tirzepatide

• GIP agonists

• Any other weight-loss injections targeting the same pathways

Combining mechanisms increases risks and does not enhance benefits.

Insurance coverage varies significantly:

• FDA-approved dual agonists may be covered under strict criteria.

• Compounded GLP-1 + GIP medications are typically not covered.

Good Girl Rx offers both:

• Insurance benefit checks for eligible FDA-approved options

• Transparent cash-pay pricing for compounded formulations

Starting treatment is simple:

1. Complete an online consultation with a licensed provider.

2. Your provider reviews your health history and determines eligibility.

3. If prescribed, your medication ships FREE and discreetly from a U.S. pharmacy.

Support continues with dose guidance, refills, and ongoing clinical care.