Semaglutide is a GLP-1 receptor agonist, a class of medications shown to help regulate hunger, appetite, digestion, and metabolic function. It works by mimicking a natural hormone that influences blood sugar levels and fullness cues.

There are FDA-approved brand-name versions of semaglutide for chronic weight management and diabetes. However, compounded semaglutide may be prescribed when appropriate and prepared by licensed compounding pharmacies.

Semaglutide is typically used along with a reduced-calorie diet and increased physical activity for best results.

Semaglutide works by activating GLP-1 receptors in the brain and digestive system. This leads to:

• Slower gastric emptying, helping you feel full longer

• Reduced appetite and cravings

• More stable blood sugar responses

• Improved insulin sensitivity

These effects may collectively support weight reduction and metabolic balance when combined with lifestyle changes.

Compounded medications are not FDA-approved, but they may be prescribed by healthcare providers when commercially manufactured alternatives are unavailable or not preferred.

Licensed compounding pharmacies follow strict state and federal guidelines to ensure quality and safety. However, because compounded semaglutide is not FDA-reviewed, it may carry additional considerations that your provider will discuss to ensure you receive appropriate care.

Many individuals begin noticing changes in appetite within the first few weeks of treatment. Weight-related changes tend to occur gradually as the dose increases.

Full therapeutic benefits often appear over several weeks to months, depending on consistency, dose titration, and individual metabolic factors.

Semaglutide may be appropriate for adults with obesity or overweight with weight-related health concerns, as determined by a licensed provider.

Good candidates typically include individuals who:

• Struggle with appetite regulation

• Have metabolic challenges affecting weight

• Benefit from structured, long-term medication support

Eligibility is determined through a full medical evaluation at Good Girl Rx.

Semaglutide’s most common side effects relate to digestion. These may include:

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Stomach discomfort

These symptoms often lessen as your body adjusts. Your provider may recommend dose adjustments or lifestyle strategies to reduce discomfort.

Semaglutide is the active ingredient in both Wegovy® and Ozempic®. The key differences lie in:

• FDA-approved uses

• Dosing and delivery systems

• Branding and formulation

Compounded semaglutide is not the same as these FDA-approved drugs and is prepared by compounding pharmacies when prescribed.

No. Semaglutide should not be used with:

• Other GLP-1 agonists

• Tirzepatide medications

• Weight-loss injections targeting similar pathways

Using multiple GLP-1 or GIP medications increases the risk of side effects and is not medically recommended.

Insurance coverage varies widely. Some plans may cover FDA-approved versions of semaglutide under specific criteria, but compounded semaglutide is typically not covered.

Good Girl Rx offers:

• Insurance verification for FDA-approved alternatives

• Transparent cash-pay pricing for compounded treatments

Your provider will help determine the best clinical and financial pathway.

Starting semaglutide is simple:

1. Complete a secure online consultation with a licensed provider.

2. Your provider evaluates your health history and treatment goals.

3. If prescribed, semaglutide ships FREE from a licensed U.S. compounding pharmacy.

Ongoing clinical support is included, along with dose guidance and refill coordination.