MIC stands for methionine, inositol, and choline — three lipotropic compounds that support the liver’s ability to process and mobilize fat. Methionine is an essential amino acid that helps the liver export fat and supports methylation. Inositol plays a role in insulin signaling and fat metabolism. Choline is essential for exporting fat from the liver as part of VLDL particles — without enough choline, fat accumulates in liver cells. Adding methylcobalamin B12 supports energy, red blood cell production, and overall metabolic function.

MIC + B12 is not a standalone weight loss drug — it’s a metabolic support injection designed to work alongside a calorie-controlled diet, exercise, and in many cases GLP-1 therapy. Think of it as a tool that helps your liver process fat efficiently and keeps your energy up while your overall program does the actual work of reducing body fat. Expectations set accordingly: it supports, it doesn’t replace, the fundamentals.

Yes — this is one of the most common pairings we prescribe. GLP-1 medications reduce appetite and food intake, while MIC + B12 supports the metabolic pathways your body uses to mobilize and burn stored fat. Many women on GLP-1 therapy also report that the B12 component helps counteract some of the fatigue that can come during early titration. Your provider will confirm the combination is appropriate for your history during intake.

MIC + B12 is given as a subcutaneous or intramuscular injection, typically once or twice weekly depending on your provider’s protocol. The injection is small, the needle is tiny, and the whole process takes under a minute. Your first shipment includes the medication, syringes, alcohol swabs, and a step-by-step guide. Your care team is available through the Patient Portal if you want help with your first injection.

MIC + B12 is generally well tolerated. The most common side effects are mild: injection site redness or soreness, a brief warm flushing sensation, occasional nausea, or a mild stomach ache. Some patients notice their urine has a slightly stronger odor from the methionine and choline — this is normal. Contact your provider if you experience persistent nausea, rash, difficulty breathing, or any sign of an allergic reaction.

Do not use if you have a known hypersensitivity to any ingredient in the formulation. It is contraindicated in patients with homocystinuria (a rare genetic disorder affecting methionine metabolism), Leber’s hereditary optic neuropathy, or any condition causing abnormal cobalt metabolism. Not recommended during pregnancy or breastfeeding without provider approval. Patients with severe liver or kidney disease should discuss with their provider before starting. Disclose all medications and conditions during intake.