PT-141, also known as bremelanotide, is a synthetic peptide that activates melanocortin receptors in the hypothalamus — the part of the brain responsible for regulating sexual desire and motivation. Unlike traditional therapies that work on blood flow, PT-141 targets the neurological pathways behind arousal.

An FDA-approved version of bremelanotide (Vyleesi®) is indicated for premenopausal women with hypoactive sexual desire disorder (HSDD). When prescribed through Good Girl Rx, PT-141 is prepared in compounded form by independent, U.S.-licensed pharmacies.

PT-141 stimulates melanocortin-4 receptors (MC4R) in the central nervous system. This activates the brain’s natural pathways for sexual desire and arousal — enhancing the “want to,” not just the physical ability. It’s administered as a simple subcutaneous injection approximately 45 minutes before anticipated intimacy.

Effects typically begin within 45–60 minutes and can last several hours. It is used as-needed, not daily.

Vyleesi® is the FDA-approved brand name for bremelanotide, indicated for HSDD in premenopausal women. When prescribed through Good Girl Rx, PT-141 is prepared as a compounded formulation by independent, state-licensed pharmacies. Compounded medications are not FDA-approved but are prepared in accordance with applicable state and federal regulations.

Most women report feeling effects within 45 to 60 minutes after injection. The duration varies by individual but can last several hours. Your provider will help set expectations based on your health history and goals.

PT-141 may be appropriate for women experiencing low sexual desire that causes personal distress. It is not intended for sexual dysfunction caused by underlying medical conditions, psychiatric disorders, or relationship issues. A licensed provider will review your complete health history during the intake process to determine eligibility.

Your provider will review your current medications during evaluation. PT-141 should not be used with certain blood pressure medications. Always disclose all medications, supplements, and health conditions during your intake. Do not combine PT-141 with other sexual wellness treatments without provider approval.

The most commonly reported side effects include:

• Nausea (most common, especially after first use — typically resolves within a few hours)
• Flushing
• Headache
• Injection site reactions

Your provider may recommend an anti-nausea medication for initial doses. Do not use more than one dose in 24 hours or more than 8 doses per month.

No. Compounded medications are not FDA-approved. They are prepared by state-licensed (503A) or FDA-registered (503B) compounding pharmacies. The FDA does not verify compounded preparations for safety or effectiveness. An FDA-approved version of bremelanotide (Vyleesi®) exists for the treatment of HSDD in premenopausal women.

Getting started is simple:

• Complete a secure online intake at care.goodgirlrx.com
• A licensed provider reviews your information and conducts a clinical evaluation
• If prescribed, your medication is compounded and shipped in discreet packaging directly to your door
• Message your provider anytime through your Patient Portal for follow-up questions

Good Girl Rx does not require or accept insurance. All pricing is transparent and all-inclusive — medication, supplies, and shipping are included in your plan.

• FSA & HSA cards are accepted for 3-month or longer plans
• Itemized receipts are provided for self-submission to your benefits provider